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The nature of the emergency wasn't immediately revealed. But TMZ and RadarOnline report Locklear, 50, may have mixed alcohol and prescription medication.
"Emergency response personnel responded to a medical emergency call at Ms. Locklear's residence," Ventura County Sheriff's Capt. Mike Aranda tells PEOPLE. "Once they arrived, it was determined that Ms. Locklear needed to be transported to the hospital for further medical attention."
He adds that hospital personnel are "taking care of her situation."
TMZ reports that a sister for Locklear called 911 from the home northwest of Los Angeles and that the actress was taken by ambulance to the hospital.
The Melrose Place star was hospitalized in December 2010 for a bacterial infection. Last November, she and Jack Wagner called off their engagement.
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